Assistant Prof. Chang, An-Yi

Laboratory：EN1018-1

Office Position：EN4045

Tel：07-5252000 #4219 (Office)  #4247 (Lab)

E-mail：aychang@mail.nsysu.edu.tw

學歷 (Education)

• Louisiana Tech University, Engineering, with concentration in Micro & Nanoscale Systems, Doctor of Philosophy (2014~2017)
• Louisiana Tech University, Department of Chemical Engineering, Master of Science in Engineering (2011~2014)
• Feng-Chia University, Department of Chemical Engineering, Bachelor of Science (2004~2008)

經歷 (Work Experience)

• 2021~2025：University of California San Diego, Postdoctoral Scholar
• 2018~2020：Louisiana Tech University, Postdoctoral Researcher/ Research Scientist

專業領域 (Fields of Expertise)

• Wearable Biosensors
• Lab-on-a-Chip
• Microneedle Sensors
• Nanomaterials and Nanofabrication
• Neurochemical Sensor Development
• Flexible Electronics for Biomedical Engineering Applications

期刊論文(Journal Papers)

1.  Chang, A. Y., Djassemi, O., Dugas, Y. & McGregor, I. From material innovation to clinical translations: Interface stability and AI-enabled wearable health tracking. Next Bioengineering 3, 100038 (2026).

2.   Jakab, K. et al. Integrated Electrochemical Aptasensor−Polymer Inclusion Membrane Platform for Detecting Oxytetracycline in Raw Milk. ACS Sens. 11, 4269–4274 (2026).

3.   Shukla, S. et al. Chemically Selective Nanoelectrode Arrays for Real-Time, Parallel Neurotransmitter and Electrical Recording. Small Science 6, e70249 (2026).

4.   Djassemi, O. et al. Clinical Evaluation of Microneedle Biosensors for Continuous Lactate Monitoring in Critically Ill Patients. ACS Sens. 11, 1413–1424 (2026).

5.   Djassemi, O. et al. Continuous lactate monitoring for real-time fatigue assessment in baseball pitchers. Biosens. Bioelectron. 304, 118611 (2026).

6.   de la Asunción-Nadal, V. et al. Photo-magnetically actuated biohybrid microrobots. Matter 9, (2026).

7.   Reynoso, M. et al. Automated dip-coating surface modification system for microneedle sensors. Device 4, (2026).

8.   Chang, A. Y. et al. Integration of chemical and physical inputs for monitoring metabolites and cardiac signals in diabetes. Nature Biomedical Engineering 2025 10:1 10, 94–109 (2025).

9.   Boscarino, T. et al. Monitoring blood lactate dynamics through sweat and interstitial fluid biofluids. Talanta 298, 128985 (2026).

10. Ding, S. et al. Artificial intelligence-enabled wearable microgrids for self-sustained energy management. Nature Reviews Electrical Engineering 2025 2:10 2, 683–693 (2025).

11. Li, Z. et al. Picoeukaryote-based biohybrid microrobots for active delivery in the kidney. Science Advances 11, (2025).

12. Djassemi, O. et al. A Touch Enabled Hemodynamic and Metabolic Monitor. Advanced Science 12, 2502138 (2025).

13. Moonla, C. et al. Microneedle-Based Multiplexed Monitoring of Diabetes Biomarkers: Capabilities Beyond Glucose Toward Closed-Loop Theranostic Systems. ACS Sens. 10, 5363–5379 (2025).

14. Li, Z. et al. Inhalable biohybrid microrobots: a non-invasive approach for lung treatment. Nature Communications 2025 16:1 16, 666- (2025).

15. Askarinam, N. et al. Sublingual microrobotic pills for rapid and efficient drug delivery. Nanoscale Adv. 7, 4730–4739 (2025).

16. Nandhakumar, P. et al. Simultaneous and Rapid Detection of Glucose and Insulin: Coupling Enzymatic and Aptamer-Based Assays. Anal. Chem. 96, 18806–18814 (2024).

17. Ding, S. et al. A fingertip-wearable microgrid system for autonomous energy management and metabolic monitoring. Nature Electronics 2024 7:9 7, 788–799 (2024).

18. Zhou, J. et al. Submersible voltammetric sensing probe for rapid and extended remote monitoring of opioids in community water systems. Microchimica Acta 2024 191:8 191, 463- (2024).

19. Moonla, C. et al. Continuous Ketone Monitoring via Wearable Microneedle Patch Platform. ACS Sens. 9, 1004–1013 (2024).

20. Reynoso, M. et al. 3D-printed, aptamer-based microneedle sensor arrays using magnetic placement on live rats for pharmacokinetic measurements in interstitial fluid. Biosens. Bioelectron. 244, 115802 (2024).

21. Ruiz-Valdepeñas Montiel, V. et al. Decentralized ORP Measurements for Gut Redox Status Monitoring: Toward Personalized Gut Microbiota Balance. Anal. Chem. 96, 480–487 (2023).

22. Chang, A. Y. et al. Electrochemically Induced Conformational Change of Di-Boronic Acid-Functionalized Ferrocene for Direct Solid-State Monitoring of Aqueous Fluoride Ions. Adv. Funct. Mater. 33, 2303968 (2023).

23. Singh, N. K., Chung, S., Chang, A. Y., Wang, J. & Hall, D. A. A non-invasive wearable stress patch for real-time cortisol monitoring using a pseudoknot-assisted aptamer. Biosens. Bioelectron. 227, 115097 (2023).

24. Pei, Y. et al. Nanofiber-in-microfiber carbon/silicon composite anode with high silicon content for lithium-ion batteries. Carbon N. Y. 203, 436–444 (2023).

25. Sandhu, S. S. et al. MIP-202 catalyst-integrated solid-contact potentiometric chloride sensor for versatile multiphasic detection of a sulfur mustard simulant. Sens. Actuators B Chem. 375, 132818 (2023).

26. Yin, L. et al. Wearable E-Skin Microgrid with Battery-Based, Self-Regulated Bioenergy Module for Epidermal Sweat Sensing. Adv. Energy Mater. 13, 2203418 (2023).

27. Moon, J. M. et al. Self-Testing of Ketone Bodies, along with Glucose, Using Touch-Based Sweat Analysis. ACS Sens. 2023-November, 3973–3981 (2022).

28. Chang, A. Y., Siddiqui, S. & Arumugam, P. U. Nafion and Multiwall Carbon Nanotube Modified Ultrananocrystalline Diamond Microelectrodes for Detection of Dopamine and Serotonin. Micromachines 2021, Vol. 12, Page 523 12, 523 (2021).

29. Pei, Y. et al. Nitrogen-doped carbon dots from Kraft lignin waste with inorganic acid catalyst and their brain cell imaging applications. AIChE Journal 67, e17132 (2021).

30. Chang, A. Y. et al. Dopamine sensing with robust carbon nanotube implanted polymer micropillar array electrodes fabricated by coupling micromolding and infiltration coating processes. Electrochim. Acta 368, 137632 (2021).

31. Liu, X. et al. Robust three-dimensional nanotube-in-micropillar array electrodes to facilitate size independent electroporation in blood cell therapy. Lab Chip 21, 4196–4207 (2021).

32. Chang, A. Y. et al. Microfluidic Electroporation Coupling Pulses of Nanoseconds and Milliseconds to Facilitate Rapid Uptake and Enhanced Expression of DNA in Cell Therapy. Scientific Reports 2020 10:1 10, 6061- (2020).

33. Pei, Y. et al. Confining sulfur particles in clay nanotubes with improved cathode performance of lithium–sulfur batteries. J. Power Sources 450, 227698 (2020).

34. Zu, Y., Liu, X., Chang, A. Y. & Wang, S. Flow micropillar array electroporation to enhance size specific transfection to a large population of cells. Bioelectrochemistry 132, 107417 (2020).

35. Chang, A. Y., Dutta, G., Siddiqui, S. & Arumugam, P. U. Surface Fouling of Ultrananocrystalline Diamond Microelectrodes during Dopamine Detection: Improving Lifetime via Electrochemical Cycling. ACS Chem. Neurosci. 10, 313–322 (2018).

36. Mahato, K. et al. Hybrid multimodal wearable sensors for comprehensive health monitoring. Nature Electronics 2024 7:9 7, 735–750 (2024).

37. Cheng, W. C., He, Y., Chang, A. Y. & Que, L. A microfluidic chip for controlled release of drugs from microcapsules. Biomicrofluidics 7, (2013).